The term leukemia refers to a group of red bone marrow cancers in which abnormal white blood cells multiply uncontrollably. The accumulation of the white cancerous white blood cells in red bone marrow interferes with the production of red blood cells, white blood cells, and platelets. As a result of oxygen-carrying capacity of the blood is reduced, an individual is more susceptible to infection, and blood clotting is abnormal. In most leukemias, the cancerous white blood cells spread to the lymph nodes, liver, and spleen, causing them to enlarge. All leukemias produce the usual symptoms of anemia (fatigue, intolerance of cold, and pale skin). In addition, weight loss, fever, night sweats, excessive bleeding, and recurrent infections may occur.
In general, leukemias are classified as acute (symptoms develop rapidly) and chronic (symptoms may take years to develop). Adults may have either types, but children usually have the acute type.
The cause of most types of leukemia is unknown. However, certain risk factors have been implicated. These include exposure to radiation or chemotherapy for other cancers, genetics (some genetic disorders such as Down syndrome), environmental factors (smoking and benzene), and microbes such as the human T cell leukemia-lymphoma virus-1 (HTLV-1) and the Epstein-Barr virus.
Treatment options include chemotherapy, radiation, stem cell transplantation, interferon, antibodies, and blood transfusion.
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